You are a biochemistry specialist who has been asked to provide

BIOCHEMISTRY Competency 208.5.1: DNA, RNA – The graduate demonstrates how nucleic acid polymers can transform cells and transmit information within the cell. Introduction: Although there is much talk in the news about stem cell research, the public and policymakers need to understand how basic body cells work to transmit information and replicate to facilitate more informed decisions. Scenario: You are a biochemistry specialist who has been asked to provide information on the role of DNA and RNA in the transmission of information within the cell. The audience for your report is a group of medical paraprofessionals at a community health center. Requirements: Assemble your work in a document (e.g., Microsoft Word, Google Document) (suggested length of 2–4 pages, including diagrams, text explanations, and references) for medical paraprofessionals in the scenario. Note:

Please save submission documents as *.doc, *.docx, *.rtf, or *.pdf files. If you are using Google Documents, you must save the file in *.pdf format and upload the *.pdf file. A. Create an original diagram, or series of diagrams, with clear labels, that demonstrates the process of DNA replication at the biochemical level. 1. Describe the function of the enzymes (enzyme names end in “-ase”) as part of the labels for the diagram(s) you created in part A. 2. Label the following components in your diagram(s): • DNA • replication fork • helicase • single-stranded binding proteins • leading strand template DNA • lagging strand template DNA • 5’ and 3’ ends of all DNA • primase • RNA primer • DNA polymerase III • Okazaki fragments B. Create an original diagram, or series of diagrams, with clear labels that show the role of the ligase enzyme in the replication of DNA. 1. Describe the function of the enzymes as part of the labels for the diagrams(s) you created in part B. 2. Label the following components in your diagram(s): • DNA • Okazaki fragments • DNA polymerase I • DNA ligase C. Create an original diagram, or series of diagrams, with clear labels, that demonstrates the role of mRNA in transcription and translation. 1. Describe the function of the enzymes as part of the labels for the diagram(s) you created in part C. 2. Label the cellular locations of each process. 3. Label the following transcription components in your diagram(s): • DNA • mRNA • RNA polymerase • nucleus 4. Label the following translation components in your diagram(s): • mRNA • ribosome • tRNA • amino acids • growing protein/polypeptide • cytoplasm D. Explain the role of RNA polymerase inhibition in causing the poisonous effect of the death cap mushroom, based on your knowledge of the role of mRNA. Note: For definitions of terms commonly used in the rubric, see the Rubric Terms web link included in the Evaluation Procedures section. Note: When using sources to support ideas and elements in an assessment, the submission MUST include APA formatted in-text citations with a corresponding reference list for any direct quotes or paraphrasing. It is not necessary to list sources that were consulted if they have not been quoted or paraphrased in the text of the assessment. Note: No more than a combined total of 30% of a submission can be directly quoted or closely paraphrased from sources, even if cited correctly. For tips on using APA style, please refer to the APA Handout web link included in the General Instructions section.